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Pubblicazioni di R&I

Lavori pubblicati dal 2000

D'ANDREA G, LEON A. Pathogenesis of migraine: from neurotransmitters to neuromodulators and beyond. Neurol Sci. 2010 Jun;31 Suppl 1:S1-7.

D'ARRIGO A, COLAVITO D, PEÑA-ALTAMIRA E, FABRIS M, DAM M, CONTESTABILE A, LEON A. Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease? J Mol Neurosci. 2010 Jul;41(3):404-15. Epub 2010 Feb 23.

IMBIMBO BP, GIARDINO L, SIVILIA S, GIULIANI A, GUSCIGLIO M, PIETRINI V, DEL GIUDICE E, D'ARRIGO A, LEON A, VILLETTI G, CALZÀ L. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2010 Apr;20(1):159-73.

D'ANDREA G, NORDERA G, PIZZOLATO G, BOLNER A, COLAVITO D, FLAIBANI R, LEON A. Trace amine metabolism in Parkinson's disease: low circulating levels of octopamine in early disease stages. Neurosci Lett. 2010 Jan 29;469(3):348-51. Epub 2009 Dec 21.

FLOREANI A, LAZZARI R, MACCHI V, PORZIONATO A, VARIOLA A, COLAVITO D, LEON A, GUIDO M, BALDO V, DE CARO R, BERGASA NV. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. J Gastroenterol. 2010;45(1):68-76.

COLAVITO D, CARTEI G, DAL BIANCO M, STECCA A, ZUSTOVICH F, DALLE CARBONARE M, RAGAZZI E, FARINA M, COLOMBRINO E, LEON A. Thymidylate synthetase allelic imbalance in clear cell renal carcinoma. Cancer Chemother Pharmacol. 2009 Nov;64(6):1195-200. Epub 2009 Mar 22.

AGOSTINI M, PASETTO LM, PUCCIARELLI S, TERRAZZINO S, AMBROSI A, BEDIN C, GALDI F, FRISO ML, MESCOLI C, URSO E, LEON A, LISE M, NITTI D. Glutathione S-Transferase P1 Ile105Val Polymorphism is Associated with Haematological Toxicity in Elderly Rectal Cancer Patients Receiving Preoperative Chemoradiotherapy. Drugs Aging. 2008;25(6):531-9.

DALLE CARBONARE M., DEL GIUDICE E., STECCA A., COLAVITO D., FABRIS M., D’ARRIGO A., BERNARDINI D., DAM M. AND LEON A.: A Saturated N-Acylethanolamine Other than N-Palmitoyl Ethanolamine with Anti-inflammatory Properties: a Neglected Story… Journal of Neuroendocrinology 20 (Suppl. 1), 26–34 (2008).

IMBIMBO BP, DEL GIUDICE E, COLAVITO D, D'ARRIGO A, DALLE CARBONARE M, VILLETTI G, FACCHINETTI F, VOLTA R,VLADIMIRO PIETRINI V, BAROC MF, SERNEELS L, DE STROOPER B and LEON A: CHF5074, a Novel γ-Secretase Modulator, Reduces Brain β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Disease without Causing Peripheral Toxicity. J Pharmacol Exp Ther., 323(3):822-30 (2007).

CAGNIN A, ZAMBON A, ZARANTONELLO G, VIANELLO D, MARCHIORI M, MERCURIO D, MICCICHÈ F, ERMANI M, LEON A, BATTISTIN L.: Serum lipoprotein profile and APOE genotype in Alzheimer's disease. J Neural Transm Suppl.;(72):175-9 (2007).

DEL GIUDICE E, NOFRATE V, FACCHINETTI F, PHD; BOCCACCIO P, MINELLI T, DAM M, LEON A; MOSCHINI G: 50 Hz Electromagnetic Field Exposure Stimulates Secretion of beta-Amyloid Peptide In Cultured Human Neuroglioma. Neurosci Lett. 11;418(1):9-12 (2007).

FRANCESCHI C, BEZRUKOV V, BLANCHÉ H, BOLUND L, CHRISTENSEN K, DE BENEDICTIS G, DEIANA L, GONOS E, HERVONEN A, YANG H, JEUNE B, KIRKWOOD TB, KRISTENSEN P, LEON A, PELICCI PG, PELTONEN L, POULAIN M, REA IM, REMACLE J, ROBINE JM, SCHREIBER S, SIKORA E, SLAGBOOM PE, SPAZZAFUMO L, STAZI MA, TOUSSAINT O, VAUPEL JW.: Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Ann N Y Acad Sci. 1100:21-45 (2007).

DEL GIUDICE E., RINALDI L.,  PASSAROTTO M, FACCHINETTI F., D’ARRIGO A, GUIOTTO A, BATTISTIN L and LEON A.: Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 cells. J Leukocyte Biol  81: 1512-1522 (2007)

IMBIMBO BP, DEL GIUDICE E, CENACCHI V, VOLTA R, VILLETTI V, FACCHINETTI F, RICCARDI B, PUCCINI P, LEON A. In vitro and in vivo profiling of CHF5022 and CHF5074, two novel β-amyloid1-42 lowering agents. Pharmacol Res. 55(4):318-28 (2007).

LISI V, PATERNOSTER DM, STECCA A, MICCICHE’ F, FANTINATO S, LEON A, DAMANTE G, FABBRO D, CLEMENTI M: Investigation of endothelin-1 type a receptor gene (-231 G>A polymorphism) in the pre-eclamsia susceptibility. J Matern Fetal Neonatal Med. 20(2):145-9 (2007).

MARCHET A, MOCELLIN S, BELLUCO C, AMBROSI A, DE MARCHI F, MAMMANO E, DIGITO M, LEON A., D’ARRIGO A, LISE M, NITTI D: Gene expression profile of primary gastric cancer: towards the prediction of lymph node status. Ann Surg Oncol 14(3): 1058-64 (2007)

TERRAZZINO S., AGOSTINI M., PUCCIARELLI S., URSO E., RUSSO M.V., PASETTO L.M., FRISO M.L., AMBROSI A., LISI V., LEON A., NITTI D., LISE M.: A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation. Pharmacogenetics and Genomics 16: 817-824 (2006)

FACCHINETTI F., FASOLATO C., DEL GIUDICE E., BURGO A., FUREGATO S., FUSCO M., BASSO E., SERAGLIA R., D’ARRIGO A. and LEON A.: Nimodipine selectively stimulates ß-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage Neurobiology of Aging. 27: 218-227 (2006)

RINALDI L., GALLO P., CALABRESE M., MOTTA M., RANZATO F., GUGLIELMO A., DEL GIUDICE E., ROMUALDI C., DALLE CARBONARE M., BATTISTIN L. and LEON A.: Longitudinal analysis of immune cell phenotypes in early stage multiple sclerosis: distinctive patterns characterize MRI-active patients. Brain 129:1993-2007 (2006)

DALLE CARBONARE M., TONIDANDEL L., BERTO F., LUISE D., MADREGAN A., GIORDANO G., GUIOTTO A., LEON A. and TRALDI P.: Identification of an unusual naturally-occurring fatty acid amide in mammalian brain and method for its determination. Rapid Communication in Mass Spectrometry 20: 353-360 (2006)

LISI V., GARBO G., BATTISTELLA P.A., MICCICHE’ F., STECCA A., TERRAZZINO S., FRANZOI M., TRIPOLI E., LEON A. and CLEMENTI M.: Endothelin receptor A-231G>A polymorphism: no linkage to primary pediatric headache. Headache 46: 483-491 (2006)

MASSACESI C., TERRAZZINO S., MARCUCCI F., ROCCHI M.B., CAPPELLETTI C., BISONNI R., LIPPE P., LOMBARDO M., RINALDI L., PILONE A., GIUSTIZI L., MATTIOLI R., LEON A. and MONSIGNORI M.: Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy. Cancer  106: 1007-1016 (2006).

LISI V., GARBO G., MICCICHE’ F., STECCA A., TERRAZZINO S., FRANZOI M., TRIPOLI E., CLEMENTI M., LEON A., and BATTISTELLA P.A.: Genetic risk factors in primary pediatric versus adult headache: complexities and problematics. J Headache Pain 6:179-181 (2005).

BLANDINI F., RINALDI L., TASSORELLI C., SANCES G., MOTTA M., SAMUELE A., FANCELLU R., NAPPI G., and LEON A: Peripheral levels of BDNF and NGF in primary headaches. Cephalgia, 26: 136-142 (2005).

BALBI T., FUSCO M., VASAPOLLO D., BOSCHETTO R., COCCO P., LEON A. and FARRUGGIO A. The Presence of Trace Amines in Post-mortem Cerebrospinal Fluid in Humans. The Journal of Forensic Science. May;50(3):630-2 (2005)

D’ARRIGO A., BELLUCO C., AMBROSI A., DIGITO M., ESPOSITO G., BERTOLA A., FABRIS M., NOFRATE V., MAMMANO E., LEON A., NITTI D. and LISE M.: A metastatic transriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. International Journal of Cancer 1;115(2):256-62 (2005)

TERRAZZINO S., BERTO F., DALLE CARBONARE M., FABRIS M., GUIOTTO A., BERNARDINI D. and LEON A.: Stearoylethanolamide exerts anorexic effects in mice via downregulation of liver stearoyl-Coenzyme A desaturase-1 mRNA expression. FASEB J 18(13):1580-2 (2004).

FACCHINETTI F., DEL GIUDICE E., FUREGATO S., PASSAROTTO M., ARCIDIACONO D., and LEON A.: Dopamine inhibits responses of astroglia-enriched cultures to lipopolysaccaride via a ß-adrenoreceptor-mediated mechanism. Journal of Neuroimmunology 150(1-2): 29-36 (2004).

D’ANDREA G., TERRAZZINO S., LEON A., FORTIN D., PERINI F., GRANELLA F. and BUSSONE G.: Elevated levels of circulating trace amines in primary headaches. Neurology 62: 1701-1705 (2004)

FACCHINETTI F., DEL GIUDICE E., FUREGATO S., PASSAROTTO M. and LEON A.: Cannabinoids ablate release of TNF-Alpha in rat microglial cells stimulated with lypopolysaccharide. Glia 41: 161-168 (2003).

D’ANDREA G., TERRAZZINO S., FORTIN D., FARRUGGIO A., RINALDI L. and LEON A.: HPLC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine receptors in circulating leucocytes Neuroscience Letters 346: 89-92 (2003).

D'ANDREA G., TERRAZZINO S., FORTIN D., COCCO P., BALBI T. and LEON A. Elusive amines and primary headaches: historical background and prospectives. Neurol Sci May;24 Suppl 2:S65-7 (2003)

FUSCO M., D'ANDREA G., MICCICHE' F., STECCA A., BERNARDINI D. and LEON CANANZI A. Neurogenic inflammation in primary headaches. Neurol Sci May;24 Suppl 2:S61-4 (2003)

TERRAZZINO S., BAULEO A., BALDAN A. and LEON A.: Peripheral LPS administrations up-regulate Fas and FasL on brain microglial cells: a brain protective or pathogenic event? Journal of Neuroimmunology, 124: 45-53 (2002).

FACCHINETTI F., FUREGATO S., TERRAZZINO S. and LEON A.: H2O2-induces upregulation of Fas and Fas ligand expression in NGF-differentiated PC12 cells: modulation by cAMP. Journal of Neuroscience Research 69: 178-188 (2002).

FACCHINETTI F., TERRAZZINO S., D’ARRIGO A., RINALDI L. and LEON A.: Neurotrophic factors in the therapy of Parkinson’s Disease. Functional Neurology 16(1): 45-56 (2001).